Collagenase SANTYL® Ointment is indicated for debriding chronic dermal ulcers and severely burned areas. Occasional slight transient erythema has been noted in surrounding tissue when applied outside the wound. One case of systemic hypersensitivity has been reported after 1 year of treatment with collagenase and cortisone.
Use of Collagenase SANTYL® Ointment should be terminated when debridement is complete and granulation tissue is well established.
See complete prescribing information for more details.
References: 1. Ayello EA, Cuddigan JE. Debridement: Controlling the necrotic/cellular burden. Adv Skin Wound Care. 2004;17:66-75. 2. Milne CT, Corbett LQ. (ed). Wound, Ostomy and Continence Nursing Secrets. Philadelphia, PA: Hanley & Belfus, 2003. 3. Shi L, Carson D. Collagenase Santyl ointment: a selective agent for wound debridement. J Wound Ostomy Continence Nurs. 2009;36(6 Suppl)S12-S16. 4. Lee LK, Ambrus JL. Collagenase therapy for decubitus ulcers. Geriatrics. 1975;30:91-98. 5. Altman MI, Goldstein L, Horowitz S. Collagenase: an adjunct to healing trophic ulcerations in the diabetic patient. J Am Podiatry Assoc. 1978;68:11-15. 6. Boxer AM, Gottesman N, Bernstein H, et al. Debridement of dermal ulcers and decubiti with collagenase. Geriatrics. 1969;24:75-86. 7. Hansbrough JF, Achauer B, Dawson J, et al. Wound healing in partial-thickness burn wounds treated with collagenase ointment versus silver sulfadiazine cream. J Burn Care Rehabil. 1994;15:13-17. 8. Varma A, Bugatch E. Debridement of dermal ulcers with collagenase. Surg Gynecol Obstet. 1973;136:281-282. 9. Barrett D, Klibanski A. Collagenase debridement Amer J Nursing. 1973;73:849-851. 10. Blum G. Therapeutic evaluation of debriding agent in dermal ulcers, decubitus ulcers, and burns. Derm Digest. 1974;36. 11. Vetra H, Whittaker D. Hydrotherapy and topical collagenase for decubitus ulcers. Geriatrics. 1975;30:53-58. 12. Rao DB, Sane PG, Georgiev EL. Collagenase in the treatment of dermal and decubitus ulcers. J Am Geriatr Soc. 1975;23:22-30. 13. Zaruba F, Lettl A, Borzkova L, Skrdlantova H, Krs V. Collagenase in the treatment of ulcers in dermatology. J Hyg Epidemiol Microbiol Immunol. 1974;18:499-500. 14. Haimovici H, Strauch B. Use of collagenase in the management of stasis and ischemic ulcers of the lower extremities. In: Mandl I, ed. Collagenase. New York, NY: Gordon and Breach Science Publishers. 1971:177-183. 15. Vrabec R, Moserova J, Konickova Z, Behounkova E, Blaha J. Clinical experience with enzymatic debridement of burned skin with the use of collagenase. J Hyg Epidemiol Microbiol Immunol. 1974;18:496-497. 16. Soroff HS, Sasvary DH. Collagenase ointment and polymixin B sulfate/bacitracin spray versus SILVADENE® cream in partial thickness burns: a pilot study. J Burn Care Rehabil. 1994;15:13-17.
