5 Steps to Continuous, Active Micro-Debridement 

1. Cleanse the wound site prior to application

• Remove as much loose debris from the wound as possible
• Gently cleanse the wound bed with sterile saline, or an appropriate
  wound cleanser (optimal pH 6-8) followed by saline, each time a
  dressing is changed
• When necessary, crosshatch thick eschar with a #10 blade for optimal surface contact

2. Apply SANTYL^® Ointment

• Apply directly to the wound at 2 mm thickness
  (approximately nickel thickness)
• Avoid contact with surrounding healthy tissue

3. Maintain moisture balance

• Wounds with sufficient exudate will naturally activate the collagenase enzyme, but a dry wound bed may require additional moisture

4. Use an appropriate cover dressing

• Do not use dressings containing silver or iodine with SANTYL^® Ointment, as these ions inactivate collagenase, the active enzyme in SANTYL^® Ointment

5. Monitor use

• Reapply SANTYL^® Ointment once daily or more frequently if the dressing becomes soiled
• Discontinue use once debridement of necrotic tissue is complete and granulation tissue is well established

If infection develops:

• You may apply a topical antibiotic powder before applying SANTYL^® Ointment
• If infection persists, discontinue use of SANTYL^® Ointment until the infection is resolved