3 Steps to Continuous, Active Micro-Debridement

Application Protocol for Collagenase SANTYL^® Ointment

1. Cleanse the Wound Site

• Remove as much loose debris from the wound as possible with forceps and scissors
• Gently cleanse the wound bed with sterile saline, or an appropriate wound cleanser (optimal pH 6-8) followed by saline, each time a dressing is changed
• When necessary, crosshatch thick eschar with a #10 blade to ensure optimal surface contact

2. Apply SANTYL^® Ointment

• Apply directly to the wound or to a sterile gauze pad which is then applied to the wound and properly secured
• Apply SANTYL^® Ointment at 2 mm thickness (approximately nickel thickness)^1-4
• Carefully apply SANTYL^® Ointment within the area of the wound

3. Maintain Moisture Balance

• Wounds with sufficient exudate will naturally activate the collagenase enzyme, but a dry wound bed may require additional moisture
• Do not use dressings containing silver (Ag) or iodine (I₂) with SANTYL^® Ointment, as these ions inactivate collagenase, the active enzyme in SANTYL^® Ointment
• Apply once daily (or more frequently if the dressing becomes soiled, as from incontinence)

If infection develops:

• You may apply a topical antibiotic powder before applying SANTYL^® Ointment
• If infection persists, discontinue use of SANTYL^® Ointment until the infection is resolved