Recent Study Demonstrates
Efficacy of Enzymatic Debridement*
in Pressure Ulcers¹

Primary Study Objective

To compare collagenase* with a hydrogel† for initial debridement and promotion of ongoing debridement in subjects with pressure ulcers

Study Design

Investigators, who were blinded to randomization, evaluated weekly wound photographs for necrotic tissue debridement in subjects with pressure ulcers

Patient Demographics

Results

Enzymatic debridement* demonstrated superior efficacy versus autolytic debridement with a hydrogel† in pressure ulcers

Percentage of Patients With Complete Debridement in ≤42 Days

• Collagenase was statistically significant (P<0.003) versus hydrogel in achieving full debridement by study endpoint
• Statistical significance was reached even without crosshatching or other sharp debridement
• Reduction of nonviable tissue was greater on a weekly basis with the collagenase group as compared with the hydrogel group (P<0.002)

Study Limitations

• Small number of enrolled patients
• Results cannot be generalized to all hydrogels
• Results cannot be generalized to wounds of other etiologies or outside the long-term care setting