Compared to other debridement methods studied, patients treated with SANTYL Ointment:
In a study of patients with stage IV pressure ulcers (PU), SANTYL Ointment together with sharp debridement had lower two-year payer costs than sharp debridement alone ($11,151 vs $17,596).*29
*2015 US dollars
Outcome data were derived from retrospective deidentified electronic medical records (EMR) of patients with stage IV PU from 2007 to 2013 using the USWR
The analysis constructed a three-state Markov model over a two-year time horizon
In a study among hospital outpatients with stage III or IV PUs, SANTYL Ointment had a 14% lower one-year cost than medicinal honey ($6,161 vs $7,149).†24
†2016 US dollars
A Markov model from a US payer perspective (2016 USD) was developed with a base-case of adult patients with PUs treated in a hospital outpatient department.
In a study among DFU patients, SANTYL Ointment had a lower mean cost per responder vs saline-moistened gauze (SMG), for both in-office patients ($832 vs $1,042) and hospital outpatients ($1,607 vs $1,980).‡19
A multicenter, open-label, 12-week RCT of 48 patients with DFU
In a study among long-term care center residents with stages III and IV PUs, the direct cost for PU care per patient was $3,477 lower with SANTYL Ointment vs hydrogel, ($2,003 vs $5,480).§ The cost per PU-free day with hydrogel was 4x higher than SANTYL Ointment.29
Clinical and resource utilization data derived from a US-based, prospective, randomized, two-phase trial
In a study using a one-year time horizon from a third-party payer perspective, the expected cost per treated DFU was lower for SANTYL Ointment plus sharp debridement than for standard DFU care plus sharp debridement ($2,099 vs $2,376).||30
||2014 US dollars
Analysis of results from a randomized, open-label trial of 55 patients with DFU using a three-state Markov model
In a study comparing the impact of SANTYL Ointment vs medicinal honey on healthcare utilization in real-world hospital settings, PU patients treated with medicinal honey had greater odds of inpatient readmission after inpatient index visits.23
Analysis of SANTYL Ointment vs medicinal honey on healthcare utilization among PU inpatients and outpatients. Frequency of revisits up to six months after index encounter for SANTYL Ointment vs medicinal honey was compared with multivariate analysis.
Important Safety Information:Use of SANTYL Ointment should be terminated when debridement is complete and granulation tissue is well established.
One case of systemic hypersensitivity has been reported after 1 year of treatment with collagenase and cortisone. Occasional slight transient erythema has been noted in surrounding tissue when applied outside the wound.