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Ongoing, daily debridement can help break the cycle of inflammation13

Ongoing debridement

Involves daily removal of macroscopic and microscopic necrotic tissue from the wound surface and within the wound bed.


Episodic debridement

Involves weekly or bi-weekly removal of necrotic tissue from the surface of the wound.

The two potential paths of stalled wounds13
Initial debridement
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Inflammatory process ignited
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Necrotic burden in stalled wounds

Removing necrotic burden in stalled wounds1,13

Enzymatic debridement (SANTYL Ointment) contributes to the formation of an environment that allows for healing to progress to the proliferation phase.

Enzymatic Wet-to-dry Autolytic
support
Actively removes macroscopic necrotic tissue
Preserves healthy tissue
Selectively and actively attacks denatured collagen molecules
Assists stalled wound progression through the inflammatory phase
Prevents reaccumulation of debris
Utilizes exogenous enzymes
Passively supports endogenous enzymes
Can be painful
Effective debridement

Debridement on the wound surface and in the wound bed2,13

Effective debridement requires ongoing, daily removal of necrotic tissue on the wound surface and in the wound bed – only SANTYL Ointment removes necrotic tissue at both levels.

Episodic + autolytic support Episodic + enzymatic debridement
On the wound surface (macroscopic) Reduces microbial load and limits inflammatory response13
Reduced microbial load associated with the removal of necrotic tissue13
Selectively and actively removes necrotic tissue while preserving healthy granulation tissue13
In the wound bed (microscopic) Removes microscopic necrotic tissue to prevent reaccumulation13
Cleaves collagen at 7 sites2
Removes necrotic tissue that can lead to bacterial biofilm13
Episodic + autolytic support Episodic + enzymatic debridement
On the wound surface
Reduces microbial load and limits inflammatory response
Reduced microbial load associated with the removal of necrotic tissue
Selectively and actively removes necrotic tissue while preserving healthy granulation tissue
In the wound bed
Removes microscopic necrotic tissue to prevent reaccumulation
Cleaves collagen at 7 sites
Removes necrotic tissue that can lead to bacterial biofilm
Essential tip
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Essential tip

Why is debridement with SANTYL Ointment called ongoing, daily debridement?

Because SANTYL Ointment removes necrotic debris consistently over time rather than removing it only at the moment of debridement or relying solely on the body's natural healing mechanism.13

What's next?

Mechanism of action

Important Safety Information:Use of SANTYL Ointment should be terminated when debridement is complete and granulation tissue is well established.

One case of systemic hypersensitivity has been reported after 1 year of treatment with collagenase and cortisone. Occasional slight transient erythema has been noted in surrounding tissue when applied outside the wound.