Measurement and Application Protocol for
Collagenase SANTYL® Ointment

Depending on whether a 30-gram or 90-gram tube of SANTYL® Ointment is used, the proper length of ointment needed for wound debridement will differ. The illustrations below represent 1 gram of ointment from a 30-gram and a 90-gram tube. The images below are provided as a reference and are not intended to supersede independent clinical judgment or institutional protocols.

Measurement and Application Chart


3 easy steps for the proper application of SANTYL® Ointment

Step 1: Cleanse the wound
  • » Remove as much loose debris from the wound as possible

  • » Gently cleanse the wound bed with sterile saline or an appropriate wound cleanser (optimal pH 6–8) followed by saline, each time a dressing is changed

  • » When necessary, crosshatch thick eschar with a #10 blade to ensure optimal surface contact

Step 2: Apply Collagenase SANTYL® Ointment at 2mm (nickel thickness)
  • » Apply directly to the wound or to a sterile gauze pad, which is then applied to the wound and properly secured

  • » Apply SANTYL® Ointment at 2 mm thickness (approximately nickel thickness)

  • » Apply SANTYL® Ointment within the area of the wound

  • » Apply once daily (or more frequently if the dressing becomes soiled, as from incontinence)

Step 3: Dress the wound
  • » Wounds with sufficient exudate will naturally activate the collagenase enzyme, but a dry wound bed may require additional moisture

  • » Do not use dressings containing silver (Ag) or iodine (I2) with SANTYL® Ointment, as these ions inactivate collagenase, the active enzyme in SANTYL® Ointment


If infection develops:

  • » You may apply a topical antibiotic powder before applying SANTYL® Ointment

  • » If infection persists, discontinue use of SANTYL® Ointment until the infection is resolved

Use the dosing calculator to determine the amount of SANTYL® Ointment to apply
SANTYL<sup>®</sup> Ointment actively and selectively cleaves nexcrotic tissue without harming granulation tissue
View Collagenase SANTYL® Ointment case studies

Collagenase SANTYL® Ointment is indicated for debriding chronic dermal ulcers and severely burned areas.

Occasional slight transient erythema has been noted in surrounding tissue when applied outside the wound. One case of systemic hypersensitivity
has been reported after 1 year of treatment with collagenase and cortisone. Use of Collagenase SANTYL® Ointment should be terminated when
debridement is complete and granulation tissue is well established.

Please see complete prescribing information for more details.