Application Protocol for Collagenase SANTYL® Ointment

SANTYL® Ointment should be applied properly for best results. This guide will serve as a helpful reference for the proper application and dosing of SANTYL® Ointment.

3 easy steps for the proper application of SANTYL® Ointment

Step 1: Cleanse the wound
  • » Remove as much loose debris from the wound as possible

  • » Gently cleanse the wound bed with sterile saline or an appropriate wound cleanser (optimal pH 6–8) followed by saline, each time a dressing is changed

  • » When necessary, crosshatch thick eschar with a #10 blade to ensure optimal surface contact

Step 2: Apply Collagenase SANTYL® Ointment at 2mm (nickel thickness)
  • » Apply directly to the wound or to a sterile gauze pad, which is then applied to the wound and properly secured

  • » Apply SANTYL® Ointment at 2 mm thickness (approximately nickel thickness)

  • » Apply SANTYL® Ointment within the area of the wound

  • » Apply once daily (or more frequently if the dressing becomes soiled, as from incontinence)

Step 3: Dress the wound
  • » Wounds with sufficient exudate will naturally activate the collagenase enzyme, but a dry wound bed may require additional moisture

  • » Do not use dressings containing silver (Ag) or iodine (I2) with SANTYL® Ointment, as these ions inactivate collagenase, the active enzyme in SANTYL® Ointment


See how to properly apply SANTYL® Ointment:

Click here to view proper application of Collagenase SANTYL® Ointment


If infection develops:

  • » You may apply a topical antibiotic powder before applying SANTYL® Ointment

  • » If infection persists, discontinue use of SANTYL® Ointment until the infection is resolved

Use the dosing calculator to determine the amount of SANTYL® Ointment to apply
See how Collagenase SANTYL® Ointment works. Click here to view the mechanism of action (MOA)
View Collagenase SANTYL® Ointment case studies

Collagenase SANTYL® Ointment is indicated for debriding chronic dermal ulcers and severely burned areas.

Occasional slight transient erythema has been noted in surrounding tissue when applied outside the wound. One case of systemic hypersensitivity
has been reported after 1 year of treatment with collagenase and cortisone. Use of Collagenase SANTYL® Ointment should be terminated when
debridement is complete and granulation tissue is well established.

See complete prescribing information for more details.