Collagenase SANTYL Ointment is indicated for debriding chronic dermal ulcers and severely burned areas.

Collagenase SANTYL Ointment is indicated for debriding chronic dermal ulcers and severely burned areas.

What should I know about Collagenase SANTYL Ointment?

What is SANTYL Ointment?

SANTYL Ointment is an FDA-approved prescription medicine that removes dead tissue from wounds so they can start to heal.

Who should NOT use SANTYL Ointment?

  • Do not use SANTYL Ointment if you are allergic or sensitive to collagenase or any other ingredient in this product
  • Use this product only if it has been prescribed to you by your healthcare professional. Never share this medicine with another person, and use SANTYL Ointment only for the condition for which it was prescribed
  • Keep SANTYL Ointment and all medicines out of the reach of children
  • Always use SANTYL Ointment as instructed by your healthcare professional and according to the instructions in the product packaging

What should I avoid while using SANTYL Ointment?

  • Make sure to apply the ointment only to the wound, and not the surrounding tissue
  • Do not use products that contain lead, iodine, silver, or mercury. These ingredients may prevent the ointment from working correctly
  • Never use SANTYL Ointment in or around your eyes

What is the right amount of SANTYL Ointment to apply?

Your healthcare professional will show you how much SANTYL Ointment your wound needs. Apply the correct amount as instructed by your healthcare professional, usually at the thickness of a nickel.

Are there any side effects?

A small number of patients may experience temporary redness when they apply the ointment, especially if the medicine comes into contact with skin around the wound. If a large amount of fluid or wound material builds up, you may have irritation. If this happens, talk to your healthcare professional. He or she may tell you to change your wound dressing more frequently until the amount of wound material or drainage decreases. Let your healthcare professional know right away if you experience any ongoing side effects. You should report side effects of prescription drugs to the FDA. Call 1-800-FDA-1088 or visit

How should I store SANTYL Ointment?

Do not refrigerate SANTYL Ointment or expose it to heat. Store SANTYL Ointment at room temperature (no higher than 25°C or 77°F).

As with all medications, keep out of the reach of children.

Where can I get more information?

Ask your healthcare professional or pharmacist right away if you have any other questions or need additional information about SANTYL Ointment. It is also a good idea to read the product packaging every time you get a refill, to remind you of the right way to use the medicine.

Important Safety Information:Occasional slight temporary redness has been noted in surrounding tissue when applied outside the wound. One case of an allergic reaction has been reported after 1 year of treatment with collagenase and steroid cream. Use of SANTYL Ointment should be stopped when debridement is complete and granulation tissue is well established.