Scientifically shown to help advance wounds toward healing
In multiple clinical studies, treatment with Collagenase SANTYL◊ Ointment (in conjunction with sharp debridement) has resulted in faster reduction of wound area.12-14,17
Healthcare savings associated with early initiation of SANTYL◊ Ointment
A retrospective spending study shows how early initiation of SANTYL Ointment can provide both all‐cause and disease‐related healthcare savings to payers and providers managing patients with pressure injuries (PIs) or diabetic foot ulcers (DFUs). 26
* In all-cause pressure injury costs.
SANTYL Ointment + supportive care + sharp debridement showed a 68% average reduction in ulcer area (p<0.001)† from baseline at 6 weeks vs. the control group of supportive care* + sharp debridement only, which showed a 36% reduction (p=ns) †‡ from baseline at 6 weeks.12
* Supportive care in the SANTYL Ointment group included ALLEVYN◊ Foam Dressing, cast padding, and Coban™ bandages.
† All patients agreed to wear an offloading boot or other appropriate device.
‡ Supportive care in the control group was the clinician's choice.
SANTYL Ointment + supportive care*† + sharp debridement showed a 65% mean reduction in ulcer area (p<0.0001) from baseline at 12 weeks vs. the control group of hydrogel + supportive care*† + sharp debridement, which showed a 51% reduction (p<0.0001) from baseline at 12 weeks.13
* Supportive care: ulcers covered with daily foam dressings in both study arms
† All patients agreed to wear an offloading boot or other appropriate device.
SANTYL Ointment + supportive care* + periodic sharp debridement† showed a 62% mean reduction ulcer area (n=51) from baseline at six weeks vs. Silver products‡ + supportive care§ + periodic sharp debridement†, which showed a 40% reduction (n=51). (p<0.071)17
* Supportive care in the SANTYL Ointment group included ALLEVYN◊ Foam Dressing, cast padding, and Coban™ or equivalent bandages.
† All subjects underwent sharp debridement prior to the application of the assigned test article and as medically necessary at any of the scheduled study visits.
‡ Product containing silver was the investigator’s choice and was applied according to site procedures and the specific product’s Instructions for Use.
§ Supportive care in the control (silver) group was the clinician’s choice.
¶ SANTYL Ointment is not indicated for the treatment or prevention of infection.
SANTYL Ointment showed a 45% mean reduction in ulcer area (p=0.016) from baseline at four weeks vs. the group of sharp debridement + wet-to-dry, which showed a 0% reduction (P=ns*) from baseline at four weeks.14
* ns=not significant