See how SANTYL Ointment cleaves collagen fibers that anchor necrotic tissue to the wound bed to free a wound of necrotic debris1
The enzyme in SANTYL Ointment is derived from fermentation by Clostridium histolyticum. This type of collagenase works differently than the natural collagenase found in the human body. Unlike human collagenase that splits collagen in its native triple-helical conformation, exogenous bacterial collagenase possesses the unique ability to cleave at multiple sites within triple-helical regions and breaks down denatured collagen in necrotic tissue.2,13
Important Safety Information:Use of SANTYL Ointment should be terminated when debridement is complete and granulation tissue is well established.
One case of systemic hypersensitivity has been reported after 1 year of treatment with collagenase and cortisone. Occasional slight transient erythema has been noted in surrounding tissue when applied outside the wound.