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SANTYL Ointment uniquely cleaves at multiple sites on the denatured collagen molecule2,13

SANTYL Ointment uniquely cleaves at multiple sites on the denatured collagen molecule2,13

Endogenous (natural) debridement at 1 site2,13
  • Autolytic support
  • Endogenous enzymes found naturally in the body, dependent on a person’s immune system
  • Autolytic process takes time and is traditionally slow
  • Anaerobic (bacterial) growth may occur
  • Cleaves necrotic tissue at one specific site along collagen molecule
  • There are no active ingredients in any autolytic support agent that actively debrides wounds
endogenous helix
Exogenous (SANTYL Ointment) debridement at 7 sites2,13
  • Exogenous bacterial enzyme
  • Works faster and more powerfully than autolytic support
  • Cleaves necrotic tissue at 7 specific sites along the denatured collagen molecule
  • Breaks and unwinds denatured collagen
exogenous helix
Debridement at multiple layers
macroscopic layer microscopic layer

SANTYL Ointment debrides on the wound surface and within the wound bed2,13


  • Preserves healthy granulation tissue1
  • Selectively and actively debrides necrotic tissue13


  • Permeates the wound surface between pockets of dead tissue1
  • Cleaves necrotic tissue along the length of the collagen fiber14
  • Specifically breaks down all denatured collagen13
How SANTYL Ointment works

Watch video

Mechanism of action

See how SANTYL Ointment cleaves collagen fibers that anchor necrotic tissue to the wound bed to free a wound of necrotic debris1

Essential tip
Alternate Text
Essential tip

What is exogenous bacterial collagenase?

The enzyme in SANTYL Ointment is derived from fermentation by Clostridium histolyticum. This type of collagenase works differently than the natural collagenase found in the human body. Unlike human collagenase that splits collagen in its native triple-helical conformation, exogenous bacterial collagenase possesses the unique ability to cleave at multiple sites within triple-helical regions and breaks down denatured collagen in necrotic tissue.2,13

What's next?

Body of evidence

Important Safety Information:Use of SANTYL Ointment should be terminated when debridement is complete and granulation tissue is well established.

One case of systemic hypersensitivity has been reported after 1 year of treatment with collagenase and cortisone. Occasional slight transient erythema has been noted in surrounding tissue when applied outside the wound.